Posts belonging to Category 'Travaux scientifiques'

Relationships between ultrasound enthesitis, disease activity and axial radiographic structural changes in patients with early spondyloarthritis: data from DESIR cohort

Un nouvel article scientifique intitulé «Relationships between ultrasound enthesitis, disease activity and axial radiographic structural changes in patients with early spondyloarthritis: data from DESIR cohort.» a été publié dans le journal RMD Open.
Ruyssen-Witrand A, Jamard B, Cantagrel A, Nigon D, Loeuille D, Degboe Y, Constantin A.
Abstract
BACKGROUND:
To search for association between ultrasound (US) enthesis [...]

Assessment of typical SpA lesions on MRI of the spine: do local readers and central readers agree in the DESIR-cohort at baseline

Un nouvel article scientifique intitulé «Assessment of typical SpA lesions on MRI of the spine: do local readers and central readers agree in the DESIR-cohort at baseline » a été publié dans le journal Clin Rheumatol.
de Hooge M, Pialat JB, Reijnierse M, van der Heijde D, Claudepierre P, Saraux A, Dougados M, Feydy [...]

Remission is related to CRP and smoking in early axial spondyloarthritis. The DESIR cohort.

Un nouvel article scientifique intitulé «Remission is related to CRP and smoking in early axial spondyloarthritis. The DESIR cohort.» a été publié dans le journal Joint Bone Spine.
Wendling D, Guillot X, Gossec L, Prati C, Saraux A, Dougados M
Joint Bone Spine. 2016 Jul 20. doi: 10.1016/j.jbspin.2016.06.004
Abstract

INTRODUCTION:
No evaluation of factors associated with remission has been [...]

Biomarkers for outcomes of spondyloarthritis

Une nouvelle review scientifique intitulé «Biomarkers for outcomes of spondyloarthritis» a été publié dans le journal Joint Bone Spine.
Xavier Romand, Claire Douillard, Athan Baillet.
No abstract available Keywords: Adipokines; Anti-Saccharomyces cerevisiæ antibodies; Biomarkers; Calprotectin; Cytokines; Spondyloarthritis.

ACR 2017

Des nouveaux travaux ont été présentés lors du congrès du collège américain (ACR) de rhumatologie qui s’est déroulé du 3 au 8 novembre 2017 à San Diego (Etats-Unis) :
▫ Inflammation on MRI of Spine and Sacroiliac Joints Is Highly Predictive of Structural Damage in Axial Spondyloarthrisis: The 5 Years Data of [...]

SFR 2017

De nouveaux travaux ont été présentés lors du congrès de la Société Française de Rhumatologie (SFR) qui s’est déroulé du 10 au 12 décembre 2017 :
Présentations orales :
▫         La cohorte après les 10 premières années de suivi : A. Ruyssen-Witrand (Toulouse)
▫         Les données de l’imagerie après 5 ans de suivi : A. Molto (Paris)
Liste [...]

EULAR 2017

Lors du congrès de l’EULAR 2017 qui s’est déroulé à Madrid du 14 au 17 juin 2017, des abstracts ont été acceptés pour une présentation orale ou par poster :

Présentation orale
▫         Incidence of vertebral fractures in early spondyloarthritis : 5-year prospective data of the desir cohort :  J. Sahuguet et al.
▫         Evaluation of the [...]

Disease activity trajectories in early axial spondyloarthritis: results from the DESIR cohort.

Un nouvel article scientifique intitulé «Remission is related to CRP and smoking in early axial spondyloarthritis. The DESIR cohort.» a été publié dans le journal Ann Rheum Dis.
Molto A, Tezenas du Montcel S, Wendling D, Dougados M, Vanier A, Gossec L
Ann Rheum Dis. 2016 Nov 25. pii: annrheumdis-2016-209785.
Abstract
BACKGROUND:
Disease activity may change over time in axial [...]

Is the current ASAS expert definition of a positive family history useful in identifying axial spondyloarthritis? Results from the SPACE and DESIR cohorts

Un nouvel article scientifique intitulé «Is the current ASAS expert definition of a positive family history useful in identifying axial spondyloarthritis? Results from the SPACE and DESIR cohorts.» a été publié dans le journal Arthritis Res Ther.
Ez-Zaitouni Z, Hilkens A, Gossec L, Berg IJ, Landewé R, Ramonda R, Dougados M, van der Heijde [...]

Can we use structural lesions seen on MRI of the sacroiliac joints reliably for the classification of patients according to the ASAS axial spondyloarthritis criteria? Data from the DESIR cohort

Abstract
OBJECTIVES:

Investigating the utility of adding structural lesions seen on MRI of the sacroiliac joints to the imaging criterion of the Assessment of SpondyloArthritis (ASAS) axial SpondyloArthritis (axSpA) criteria and the utility of replacement of radiographic sacroiliitis by structural lesions on MRI.
METHODS:

Two well-calibrated readers scored MRI STIR (inflammation, MRI-SI), MRI T1-w images (structural lesions, MRI-SI-s) and radiographs of the sacroiliac joints (X-SI) of patients in the DEvenir des Spondyloarthrites Indifférenciées Récentes cohort (inflammatory back pain: ≥3 months, <3 years, age <50). A third reader adjudicated MRI-SI and X-SI discrepancies. Previously proposed cut-offs for a positive MRI-SI-s were used (based on <5% prevalence among no-SpA patients): erosions (E) ≥3, fatty lesions (FL) ≥3, E/FL ≥5. Patients were classified according to the ASAS axSpA criteria using the various definitions of MRI-SI-s.
RESULTS:

Of the 582 patients included in this analysis, 418 fulfilled the ASAS axSpA criteria, of which 127 patients were modified New York (mNY) positive and 134 and 75 were MRI-SI-s positive (E/FL≥5) for readers 1 and 2, respectively. Agreement between mNY and MRI-SI-s (E/FL≥5) was moderate (reader 1: κ: 0.39; reader 2: κ: 0.44). Using the E/FL≥5 cut-off instead of mNY classification did not change in 478 (82.1%) and 469 (80.6%) patients for readers 1 and 2, respectively. Twelve (reader 1) or ten (reader 2) patients would not be classified as axSpA if only MRI-SI-s was performed (in the scenario of replacement of mNY), while three (reader 1) or six (reader 2) patients would be additionally classified as axSpA in both scenarios (replacement of mNY and addition of MRI-SI-s). Similar results were seen for the other cut-offs (E≥3, FL≥3).
CONCLUSIONS:

Structural lesions on MRI can be used reliably either as an addition to or as a substitute for radiographs in the ASAS axSpA classification of patients in our cohort of patients with short symptom duration.

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
KEYWORDS:

Ankylosing Spondylitis; Low Back Pain; Magnetic Resonance Imaging; Spondyloarthritis