avril 14, 2015 | Posted by admin
Un nouvel article scientifique intitulé « Evaluation of the validity of the different arms of the ASAS set of criteria for axial spondyloarthritis and description of the different imaging abnormalities suggestive of spondyloarthritis: data from the DESIR cohort» a été publié dans le journal Annals of the Rheumatic Diseases en janvier 2014.
Moltó A, Paternotte S, van der Heijde D, Claudepierre P, Rudwaleit M, Dougados M.
Ann Rheum Dis. 2015 Apr;74(4):746-51. doi: 10.1136/annrheumdis-2013-204262. Epub 2014 Jan 3.
Abstract
BACKGROUND:
The Assessment of Spondyloarthritis International Society (ASAS) criteria for axial spondyloarthritis (SpA) allows classification of patients with (’imaging‘ arm) and without (’clinical’ arm) imaging abnormalities of the sacroiliac joints.
OBJECTIVE:
To compare the phenotype of early axial SpA with regard to the two arms of the ASAS axial SpA criteria.
METHODS:
Demographics, clinical and biological features of SpA, disease activity, severity parameters, and imaging abnormalities at the sacroiliac and spine levels were compared, in the two arms of the ASAS axial SpA criteria, in the patients of the French cohort of early SpA.
RESULTS:
Of the 615 patients analysed, 435 (70.7%) met the ASAS criteria (262 (60.2%) and 173 (39.8%) in the imaging and clinical arms, respectively). There were no major differences in the characteristics of the two groups except that those in the imaging arm were more likely to be younger, male and have higher concentrations of C-reactive protein. Imaging abnormalities other than those meeting the ASAS criteria for theimaging arm (ie, x-ray-determined structural damage or MRI-revealed inflammatory changes in the sacroiliac joint (SIJ)) were observed (MRI-SIJ structural damage (55.0% vs 3.5%), MRI-spine inflammatory changes (35.1% vs 12.9%), MRI-spine structural damage (10.3% vs 5.3%) and x-ray-syndesmophytes (11.8% vs 5.3%)) in the imaging versus clinical arm, respectively.
CONCLUSIONS:
Our study confirms the external validity of the clinical arm of the ASAS criteria. It is notable that many patients in the clinical arm showed other imaging changes in SIJs and spine.
Categories: Publication de travaux dans des journaux médicaux | 
Tags: Anna Molto, annal of rheumatic diseases, ASAS criteria, axial spondyloarthritis, cohorte, DESIR, Maxime Dougados | 
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février 12, 2015 | Posted by admin
Un nouvel article scientifique intitulé « Calculating the ankylosing spondylitis disease activity score if the conventional c-reactive protein level is below the limit of detection or if high-sensitivity c-reactive protein is used: an analysis in the DESIR cohort » a été publié dans le journal Arthritis Rhheumatology
Machado P, Navarro-Compán V, Landewé R, van Gaalen FA, Roux C, van der Heijde D.
Arthritis Rheumatol. 2015 Feb;67(2):408-13.
Abstract
OBJECTIVE:
The Ankylosing Spondylitis Disease Activity Score (ASDAS) is a composite measure of disease activity in axial spondyloarthritis. The aims of this study were to determine the most appropriate method for calculating the ASDAS using the C-reactive protein (CRP) level when theconventional CRP level was below the limit of detection, to determine how low CRP values obtained by high-sensitivity CRP (hsCRP) measurement influence ASDAS-CRP results, and to test agreement between different ASDAS formulae.
METHODS:
Patients with axial spondyloarthritis who had a conventional CRP level below the limit of detection (5 mg/liter) were selected (n = 257). The ASDAS–conventional CRP with 11 different imputations for the conventional CRP value (range 0–5 mg/liter, at 0.5-mg/liter intervals) was calculated. The ASDAS-hsCRP and ASDAS using the erythrocyte sedimentation rate (ESR) were also calculated. Agreement between the ASDAS formulae was tested.
RESULTS:
The ASDAS-hsCRP showed better agreement with the ASDAS-CRP calculated using the conventional CRP imputation values of 1.5 and 2.0 mg/liter and with the ASDAS-ESR than with other imputed formulae. Disagreement occurred mainly in lower disease activitystates (inactive/moderate disease activity). When the CRP value was <2 mg/liter, the resulting ASDAS-CRP scores may have been inappropriately low.
CONCLUSION:
When the conventional CRP level is below the limit of detection or when the hsCRP level is <2 mg/liter, the constant value of 2 mg/liter should be used to calculate the ASDAS-CRP score. There is good agreement between the ASDAS-hsCRP and ASDAS-ESR; however, formulae are not interchangeable.
Categories: Publication de travaux dans des journaux médicaux | Tags: cohorte DESIR, DESIR, Maxime Dougados, spondyloarthrites, spondyloarthritis | No Comments »
novembre 27, 2014 | Posted by admin
De nouveaux travaux ont été présentés lors du congrès du collège américain (ACR) de rhumatologie qui s’est déroulé du 14 au 19 novembre 2014 à Boston :
▫ Two Years Sacroiliac Radiographic Progression Rate and Influence of Baseline Markers of Inflammation in Recent Onset Spondyloarthritis.
▫ Factors Associated with a Poor Functional Prognosis in Early Inflammatory Back Pain: Results from the DESIR Cohort.
▫ Prevalence of MRI Spinal Lesions Typical for Axial Spondyloarthritis in Patients with Inflammatory Back Pain.
▫ Scoring of Spinal Lesions Compatible with Axial Spondyloarthritis on MRI in Clinical Practice By Local Radiologist or Rheumatologist in Desir; Comparison with Central Reading.
▫ Is It Worth to Include MRI of the Spine in the ASAS Classification Criteria for Axial Spondyloarthritis?
▫ Do TNF Alpha Inhibitors Have an NSAID Sparing Effect in Real Life in Early Axial Spa? Results from the DESIR Cohort.
▫ Is the Degree of NSAID Treatment in Early Axial Spondyloarthritis a Reflection of the physician’s Diagnosic Confidence? Results from the DESIR Cohort.
▫ Are We over-Treating with Nsaids Our Early Axial Spa Patients? Results from the DESIR Cohort.
▫ Routine Assessment of Patient Index Data (RAPID3) Provides Similar Information Compared to Ankylosing Spondylitis Specific Indices: Analyses of the DESIR French Cohort.
▫ How Should We Calculate the ASDAS If the Conventional C-Reactive Protein Is below the Limit of Detection? – an Analysis in the DESIR Cohort.
▫ How to Classify Spondyloarthritis after a Two Year Follow up? Results from the French Recent onset spondyloarthritis Cohort.
▫ Degenerative Changes of the Spine on MRI in Patients with Inflammatory Back Pain from the DESIR Cohort.
Categories: Présentation de travaux lors des congrès | Tags: | No Comments »
octobre 3, 2014 | Posted by admin
Lors du congrès de l’EULAR 2014 qui s’est déroulé à Paris du 11 au 14 juin 2014, 12 abstracts ont été acceptés pour une présentation orale ou par poster :
Présentation orale
▫ Degenerative changes of the spine on MRI in patients with inflammatory back pain from the DESIR cohort
▫ Classification of axspa based on positive imaging (radiographs and/or mri of the sacroiliac joints) by local rheumatologists or radiologists versus central trained readers in the DESIR cohort
Présentations par affiches.
▫ Is it worth to include MRI of the spine in the ASAS classification criteria for axial spondyloarthritis; data from the DESIR-cohort
▫ Scoring of spinal lesions compatible with axial spondyloarthritis on mri in clinical practice by local radiologist or rheumatologist in DESIR; comparison with central reading
▫ Reading of the sacroiliac joints on plain radiographs: agreement between clinical practice and trained central reading of the DESIR-cohort
▫ How reliable is the scoring of msasss in clinical practice in centers participating in DESIR? Comparison with the gold standard central reading
▫ Factors associated with a poor functional prognosis in early inflammatory back pain: results from the DESIR cohort
▫ Vitamin d, disease activity and co morbidities in early spondyloarthritis: data from the “DESIR” cohort
▫ Variable selection is not useful in the construction of a propensity score for the evaluation of tnf-alpha blockers’ treatment effect of in early spondyloarthritis: data from the DESIR cohort.
▫ The ankylosing spondylitis disease activity score (asdas): defining the best calculation method when the conventional c-reactive protein (crp) is below the threshold of detection – results from the DESIR cohort
▫ Prevalence of tuberculosis in early arthritis and early spondyloarthritis increased in comparison to the general population – results from ESPOIR and DESIR cohorts
▫ Prevalence of cardiovascular comorbidities already increased at onset of arthritis and axial spondyloarthritis – results from the ESPOIR and DESIR cohorts
Categories: Présentation de travaux lors des congrès | Tags: anti-TNF alpha, axial spondyloarthritis, cohorte DESIR, DESIR, EULAR, Maxime Dougados, spondyloarthrites, spondyloarthritis, Travaux scientifiques | No Comments »
octobre 3, 2014 | Posted by admin
Ci-dessous le titre des abstracts présentés lors du congrès de l’European League Against Rheumatism (EULAR) à Madrid du 12 au 15 juin 2013 :
Présentation orale
▫ « Use of non steroidal anti-inflammatory drugs and high body mass index prevent bone loss in patients with early inflammatory back pain: results from the DESIR cohort »
Présentations par affiches.
▫ « Is fatigue discriminant in early spondyloarthritis (SPA)? The DESIR early SPA cohort»
▫ « Anterior chest wall pain in recent inflammatory back pain, data from the DESIR cohort».
▫ « Efficacy of anti-TNF alpha therapy in early axial spondyloarthritis is siùilar regardless the presence of objective signs of inflammation or structural damage of the sacroiliac joints, data from the DESIR cohort»
▫ « Phenotype of patients and impact of the disease in early spondyloarthritis are similar regardless the arm of the ASAS criteria (« imaging » or « clinical ») fulfilled by the patients. Data from the DESIR cohort»
▫ « Spine and sacro-iliac imaging abnormalities suggestive of spondyloarthritis in early spondyloarthritis. Data from the DESIR cohort»
Categories: Présentation de travaux lors des congrès | Tags: anti-TNF alpha, axial spondyloarthritis, cohorte DESIR, DESIR, EULAR, spondylarthritis, spondyloarthritis | No Comments »
octobre 3, 2014 | Posted by admin
De nouveaux travaux ont été présentés lors du congrès de la Société Française de Rhumatologie (SFR) qui s’est déroulé du 01 au 03 décembre 2013 :
Présentations orales.
▫ La périostine : un nouveau marqueur de formation osseuse dans les lombalgies inflammatoires récentes. Données de la cohorte DESIR
▫ Traitement précoce par anti-TNF alfa chez des patients présentant une rachialgie inflammatoire récente : résultats de la cohorte DESIR
▫ Les anomalies sacro-iliaques, facteurs prédictifs de réponse au traitement anti-TNF alpha au long terme pour les patients atteints de spondyloarthrite axiale récente : données de la cohorte DESIR
▫ Les nouvelles données biologiques issues de la cohorte DESIR
▫ Les nouvelles données radiologiques issues de la cohorte DESIR
▫ Les anti-inflammatoires non stéroïdiens préviennent la perte osseuse chez les patients atteints de lombalgies inflammatoires récentes : données de la cohorte DESIR
▫ SA précoce : que nous enseigne la Cohorte DESIR ?
▫ L’effet thérapeutique en pratique courante des anti-TNF alpha à court terme dans les spondyloarthrites axiales récentes : les données de la cohorte DESIR
Présentations par affiches.
▫ La fatigue dans la spondylarthrite récente : une analyse de la cohorte DESIR
▫ Lecture des radiographies standards des sacro-iliaques : concordance entre la pratique clinique et la lecture centralisée après formation dans la cohorte DESIR (devenir des spondylarthropathies indifférenciées récentes)
▫ Quelle est la reproductibilité du score mSASSS dans la pratique clinique des centres participants à DESIR ? Comparaison avec une lecture centralisée comme gold standard
Session plénière.
▫ Relation entre le statut de vitamine D, les comorbidités et l’activité de la spondylarthrite dans la cohorte DESIR
Categories: Présentation de travaux lors des congrès | Tags: anti-TNF alpha, axial spondylarthritis, cohorte, cohorte DESIR, DESIR, mSASSS, périostine, rachialgie inflammatoire, SFR, Société Française de Rhumatologie, spondylarthropathie, spondyloarthrite, spondyloarthropathies, vitamine D | No Comments »
octobre 3, 2014 | Posted by admin
De nouveaux travaux ont été présentés lors du congrès du collège américain (ACR) de rhumatologie qui s’est déroulé du 25 au 30 octobre 2013 à San Diego :
Présentations orales
- Use Of Non Steroidal Anti-Inflammatory Drugs Prevent Bone Loss In Patients With Early Inflammatory Back Pain: Results From The DESIR Cohort.
- Reading Of The Sacroiliac Joints On Plain Radiographs: Agreement Between Clinical Practice and Trained Central Reading Of The DESIRCohort.
Posters
- Concordance Between ‘a Positive MRI Of The Sacroiliac joints’ Based On The Local Reading Versus a Centralised Reading: Experience From The DESIR-Cohort. Poster
- How Reliable Is The Scoring Of Msasss In Clinical Practice In Centers Participating In DESIR? Comparison With The Gold Standard Central Reading.
- Comparison Of The Performance Of The BASRI and Msasss In Patients With Early Inflammatory Back Pain From The DESIR Cohort.
- Different Imaging Abnormalities Suggestive Of Spondyloarthritis Are Present In Early Axial Spondyloarthritis. Data From The DESIR Cohort.
- Safety and Efficacy Of Etanercept In Early Non-Radiographic Axial Spondyloarthritis: A Randomized, Double-Blind, Placebo-Controlled Trial At 24 Weeks.
- Patients With Imaging Abnormalities Of The Sacroiliac Joints Are More Likely To Respond To TNF Alpha Inhibitors In Early Axial Spondyloarthritis. Data From The DESIR Cohort.
- Vitamin D Deficiency Is Associated With a More Active and Severe Disease In Early Axial Spondyloarthritis: Data From The DESIR Cohort.
- Phenotype Of Patients and Impact Of The Disease In Early Spondyloarthritis Are Similar Regardless The Arm Of The Assessment In Spondyloarthritis International Society Criteria (“imaging” or “clinical”) Fulfilled By The Patients. Data From The DESIR Cohort.
- Serum Periostin: a New Marker Of Local Bone Formation In Early Inflammatory Back Pain: results From The DESIR Cohort.
- Classification Of Axspa Based On Positive Imaging (Radiographs and/or MRI of the Sacroiliac Joints) By Local Rheumatologists Or Radiologists Versus Central Trained Readers In The DESIR-Cohort.
Categories: Présentation de travaux lors des congrès | Tags: axial spondylarthritis, axial spondyloarthritis, cohorte DESIR, Comité Scientifique, DESIR, spondyloarthropathies, Travaux scientifiques | No Comments »
octobre 3, 2014 | Posted by admin
3 posters ont été présentés lors du congrès du collège américain (ACR) de rhumatologie qui s’est déroulé du 09 au 14 novembre 2012 à Washington DC :
- Anterior chest wall pain in recent inflammatory back pain. Data from the DESIR cohort.
- DKK1 serum level is increased in recent spondyloarthritis and is associated with higher prevalence of syndesmophytes. Sclerostin is highly correlated with age. Data from the DESIR cohort.
- Diagnostic value of high sensitivity C reactive protein for early axial spondyloarthritis : Results from the DEvenir des Spondylarthropathies Indifferenciées Recentes Cohort.
Categories: Présentation de travaux lors des congrès | Tags: axial spondyloarthritis, cohorte DESIR, DESIR, DKK1 seum level, Travaux scientifiques | No Comments »
octobre 1, 2014 | Posted by admin
Bonjour,
Une nouvelle newsletter rhumatologues est maintenant disponible. Elle a été rédigée par le Pr Maxime Dougados.
Vous pouvez la consulter en cliquant ici.
Bonne lecture !
Categories: Newsletter Rhumatologues | Tags: cohorte DESIR, DESIR, Maxime Dougados, Newsletter, spondylarthropathie, Travaux scientifiques | No Comments »
octobre 1, 2014 | Posted by admin
Bonjour,
Nous mettons en ligne aujourd’hui la nouvelle Newsletter patients rédigée par le Pr Francis Berenbaum.
Pour y avoir accès, merci de cliquer ici.
Categories: Newsletter Patients | Tags: cohorte, DESIR, Fransis Berenbaum, Newsletter, spondylarthropathie | No Comments »
