octobre 3, 2014 | Posted by admin
Lors du congrès de l’EULAR 2014 qui s’est déroulé à Paris du 11 au 14 juin 2014, 12 abstracts ont été acceptés pour une présentation orale ou par poster :
Présentation orale
▫ Degenerative changes of the spine on MRI in patients with inflammatory back pain from the DESIR cohort
▫ Classification of axspa based on positive imaging (radiographs and/or mri of the sacroiliac joints) by local rheumatologists or radiologists versus central trained readers in the DESIR cohort
Présentations par affiches.
▫ Is it worth to include MRI of the spine in the ASAS classification criteria for axial spondyloarthritis; data from the DESIR-cohort
▫ Scoring of spinal lesions compatible with axial spondyloarthritis on mri in clinical practice by local radiologist or rheumatologist in DESIR; comparison with central reading
▫ Reading of the sacroiliac joints on plain radiographs: agreement between clinical practice and trained central reading of the DESIR-cohort
▫ How reliable is the scoring of msasss in clinical practice in centers participating in DESIR? Comparison with the gold standard central reading
▫ Factors associated with a poor functional prognosis in early inflammatory back pain: results from the DESIR cohort
▫ Vitamin d, disease activity and co morbidities in early spondyloarthritis: data from the “DESIR” cohort
▫ Variable selection is not useful in the construction of a propensity score for the evaluation of tnf-alpha blockers’ treatment effect of in early spondyloarthritis: data from the DESIR cohort.
▫ The ankylosing spondylitis disease activity score (asdas): defining the best calculation method when the conventional c-reactive protein (crp) is below the threshold of detection – results from the DESIR cohort
▫ Prevalence of tuberculosis in early arthritis and early spondyloarthritis increased in comparison to the general population – results from ESPOIR and DESIR cohorts
▫ Prevalence of cardiovascular comorbidities already increased at onset of arthritis and axial spondyloarthritis – results from the ESPOIR and DESIR cohorts
Categories: Présentation de travaux lors des congrès | 
Tags: anti-TNF alpha, axial spondyloarthritis, cohorte DESIR, DESIR, EULAR, Maxime Dougados, spondyloarthrites, spondyloarthritis, Travaux scientifiques | 
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octobre 3, 2014 | Posted by admin
Ci-dessous le titre des abstracts présentés lors du congrès de l’European League Against Rheumatism (EULAR) à Madrid du 12 au 15 juin 2013 :
Présentation orale
▫ « Use of non steroidal anti-inflammatory drugs and high body mass index prevent bone loss in patients with early inflammatory back pain: results from the DESIR cohort »
Présentations par affiches.
▫ « Is fatigue discriminant in early spondyloarthritis (SPA)? The DESIR early SPA cohort»
▫ « Anterior chest wall pain in recent inflammatory back pain, data from the DESIR cohort».
▫ « Efficacy of anti-TNF alpha therapy in early axial spondyloarthritis is siùilar regardless the presence of objective signs of inflammation or structural damage of the sacroiliac joints, data from the DESIR cohort»
▫ « Phenotype of patients and impact of the disease in early spondyloarthritis are similar regardless the arm of the ASAS criteria (« imaging » or « clinical ») fulfilled by the patients. Data from the DESIR cohort»
▫ « Spine and sacro-iliac imaging abnormalities suggestive of spondyloarthritis in early spondyloarthritis. Data from the DESIR cohort»
Categories: Présentation de travaux lors des congrès | Tags: anti-TNF alpha, axial spondyloarthritis, cohorte DESIR, DESIR, EULAR, spondylarthritis, spondyloarthritis | No Comments »
octobre 3, 2014 | Posted by admin
De nouveaux travaux ont été présentés lors du congrès de la Société Française de Rhumatologie (SFR) qui s’est déroulé du 01 au 03 décembre 2013 :
Présentations orales.
▫ La périostine : un nouveau marqueur de formation osseuse dans les lombalgies inflammatoires récentes. Données de la cohorte DESIR
▫ Traitement précoce par anti-TNF alfa chez des patients présentant une rachialgie inflammatoire récente : résultats de la cohorte DESIR
▫ Les anomalies sacro-iliaques, facteurs prédictifs de réponse au traitement anti-TNF alpha au long terme pour les patients atteints de spondyloarthrite axiale récente : données de la cohorte DESIR
▫ Les nouvelles données biologiques issues de la cohorte DESIR
▫ Les nouvelles données radiologiques issues de la cohorte DESIR
▫ Les anti-inflammatoires non stéroïdiens préviennent la perte osseuse chez les patients atteints de lombalgies inflammatoires récentes : données de la cohorte DESIR
▫ SA précoce : que nous enseigne la Cohorte DESIR ?
▫ L’effet thérapeutique en pratique courante des anti-TNF alpha à court terme dans les spondyloarthrites axiales récentes : les données de la cohorte DESIR
Présentations par affiches.
▫ La fatigue dans la spondylarthrite récente : une analyse de la cohorte DESIR
▫ Lecture des radiographies standards des sacro-iliaques : concordance entre la pratique clinique et la lecture centralisée après formation dans la cohorte DESIR (devenir des spondylarthropathies indifférenciées récentes)
▫ Quelle est la reproductibilité du score mSASSS dans la pratique clinique des centres participants à DESIR ? Comparaison avec une lecture centralisée comme gold standard
Session plénière.
▫ Relation entre le statut de vitamine D, les comorbidités et l’activité de la spondylarthrite dans la cohorte DESIR
Categories: Présentation de travaux lors des congrès | Tags: anti-TNF alpha, axial spondylarthritis, cohorte, cohorte DESIR, DESIR, mSASSS, périostine, rachialgie inflammatoire, SFR, Société Française de Rhumatologie, spondylarthropathie, spondyloarthrite, spondyloarthropathies, vitamine D | No Comments »
octobre 3, 2014 | Posted by admin
De nouveaux travaux ont été présentés lors du congrès du collège américain (ACR) de rhumatologie qui s’est déroulé du 25 au 30 octobre 2013 à San Diego :
Présentations orales
- Use Of Non Steroidal Anti-Inflammatory Drugs Prevent Bone Loss In Patients With Early Inflammatory Back Pain: Results From The DESIR Cohort.
- Reading Of The Sacroiliac Joints On Plain Radiographs: Agreement Between Clinical Practice and Trained Central Reading Of The DESIRCohort.
Posters
- Concordance Between ‘a Positive MRI Of The Sacroiliac joints’ Based On The Local Reading Versus a Centralised Reading: Experience From The DESIR-Cohort. Poster
- How Reliable Is The Scoring Of Msasss In Clinical Practice In Centers Participating In DESIR? Comparison With The Gold Standard Central Reading.
- Comparison Of The Performance Of The BASRI and Msasss In Patients With Early Inflammatory Back Pain From The DESIR Cohort.
- Different Imaging Abnormalities Suggestive Of Spondyloarthritis Are Present In Early Axial Spondyloarthritis. Data From The DESIR Cohort.
- Safety and Efficacy Of Etanercept In Early Non-Radiographic Axial Spondyloarthritis: A Randomized, Double-Blind, Placebo-Controlled Trial At 24 Weeks.
- Patients With Imaging Abnormalities Of The Sacroiliac Joints Are More Likely To Respond To TNF Alpha Inhibitors In Early Axial Spondyloarthritis. Data From The DESIR Cohort.
- Vitamin D Deficiency Is Associated With a More Active and Severe Disease In Early Axial Spondyloarthritis: Data From The DESIR Cohort.
- Phenotype Of Patients and Impact Of The Disease In Early Spondyloarthritis Are Similar Regardless The Arm Of The Assessment In Spondyloarthritis International Society Criteria (“imaging” or “clinical”) Fulfilled By The Patients. Data From The DESIR Cohort.
- Serum Periostin: a New Marker Of Local Bone Formation In Early Inflammatory Back Pain: results From The DESIR Cohort.
- Classification Of Axspa Based On Positive Imaging (Radiographs and/or MRI of the Sacroiliac Joints) By Local Rheumatologists Or Radiologists Versus Central Trained Readers In The DESIR-Cohort.
Categories: Présentation de travaux lors des congrès | Tags: axial spondylarthritis, axial spondyloarthritis, cohorte DESIR, Comité Scientifique, DESIR, spondyloarthropathies, Travaux scientifiques | No Comments »
octobre 3, 2014 | Posted by admin
3 posters ont été présentés lors du congrès du collège américain (ACR) de rhumatologie qui s’est déroulé du 09 au 14 novembre 2012 à Washington DC :
- Anterior chest wall pain in recent inflammatory back pain. Data from the DESIR cohort.
- DKK1 serum level is increased in recent spondyloarthritis and is associated with higher prevalence of syndesmophytes. Sclerostin is highly correlated with age. Data from the DESIR cohort.
- Diagnostic value of high sensitivity C reactive protein for early axial spondyloarthritis : Results from the DEvenir des Spondylarthropathies Indifferenciées Recentes Cohort.
Categories: Présentation de travaux lors des congrès | Tags: axial spondyloarthritis, cohorte DESIR, DESIR, DKK1 seum level, Travaux scientifiques | No Comments »
octobre 1, 2014 | Posted by admin
Bonjour,
Une nouvelle newsletter rhumatologues est maintenant disponible. Elle a été rédigée par le Pr Maxime Dougados.
Vous pouvez la consulter en cliquant ici.
Bonne lecture !
Categories: Newsletter Rhumatologues | Tags: cohorte DESIR, DESIR, Maxime Dougados, Newsletter, spondylarthropathie, Travaux scientifiques | No Comments »
octobre 1, 2014 | Posted by admin
Bonjour,
Nous mettons en ligne aujourd’hui la nouvelle Newsletter patients rédigée par le Pr Francis Berenbaum.
Pour y avoir accès, merci de cliquer ici.
Categories: Newsletter Patients | Tags: cohorte, DESIR, Fransis Berenbaum, Newsletter, spondylarthropathie | No Comments »
septembre 12, 2014 | Posted by admin
Un nouvel article scientifique intitulé « Agreement between clinical practice and trained central reading in reading of sacroiliac joints on plain pelvic radiographs. Results from the DESIR cohort » a été publié dans le journal Arthritis Rhheumatology
van den Berg R, Lenczner G, Feydy A, van der Heijde D, Reijnierse M, Saraux A, Rahmouni A, Dougados M, Claudepierre P
Arthritis Rheumatol. 2014 Sep;66(9):2403-11. doi: 10.1002/art.38738.
Abstract
OBJECTIVE:
To investigate the degree of agreement between local rheumatologists/radiologists and central trained readers (external standard) on the presence/absence of sacroiliitis on radiographs of the sacroiliac (SI) joints.
METHODS:
Patients with inflammatory back pain (duration ≥3 months but <3 years) suggestive of axial spondyloarthritis (SpA) were included in the Devenir des Spondylarthropathies Indifferérenciées Récentes (DESIR) cohort. Baseline radiographs of the SI joints were interpreted by 2 centralreaders (modified New York criteria); cases of disagreement were adjudicated by a third reader, yielding a positive or a negative result (centralreading). The same radiographs were also interpreted by local radiologists/rheumatologists and were rated as « normal, » « doubtful sacroiliitis, » « obvious sacroiliitis, » or « SI joint fusion » (local reading); positive findings were defined as « at least unilateral obvious sacroiliitis, » « bilateral obvious sacroiliitis, » or « at least unilateral fusion. » Agreement and misclassifications between central readers and between central reading versus localreading were calculated (kappa values).
RESULTS:
Interreader agreement between the central readers was moderate (κ = 0.54); 108 of 688 radiographs (15.7%) were adjudicated. According to local reading ( »at least unilateral obvious sacroiliitis »), 183 of the 688 patients (26.6%) had sacroiliitis, whereas according to central reading, 145 of 688 patients (21.1%) had sacroiliitis. Agreement between local reading and central reading was also moderate (κ = 0.55); 76 of 183 patients (41.5%) with « at least unilateral obvious sacroiliitis » (positive by local reading) and 32 of 109 patients (29.4%) with « bilateral obvious sacroiliitis » or « at least unilateral fusion » (positive by local reading) were rated as « negative » by central reading, and 38 of 505 patients (7.5%) and 68 of 579 patients (11.7%), respectively, without sacroiliitis (negative by local reading) were interpreted as « positive » by central reading.
CONCLUSION:
In patients with recent-onset inflammatory back pain, both trained readers and local rheumatologists/radiologists agreed only moderately on the recognition of radiographic sacroiliitis. A significant proportion of locally recognized ankylosing spondylitis (AS) patients were not confirmed as having AS by central reading (false positive), while a small minority of patients were false negative, indicating the necessity of reevaluating the role of radiographic sacroiliitis as diagnostic criterion for axial SpA.
Categories: Publication de travaux dans des journaux médicaux | Tags: cohorte DESIR, DESIR, spondyloarthritis | No Comments »
septembre 12, 2014 | Posted by admin
Un nouvel article scientifique intitulé «Early tumor necrosis factor α antagonist therapy in everyday practice for inflammatory back pain suggesting axial spondyloarthritis: results from a prospective multicenter french cohort.» a été publié dans le journal Arthritis Care Research
Canouï-Poitrine F1, Poulain C, Molto A, Le Thuaut A, Lafon C, Farrenq V, Ferkal S, Le Corvoisier P, Ghaleh B, Bastuji-Garin S, Fautrel B, Dougados M,Claudepierre P.
Arthritis Care Res (Hoboken). 2014 Sep;66(9):1395-402. doi: 10.1002/acr.22330
Abstract
OBJECTIVE:
To determine the frequency of and factors associated with early tumor necrosis factor α (TNFα) antagonist therapy in everyday clinical practice in patients with suspected axial spondyloarthropathy (SpA).
METHODS:
We used data from the prospective observational study in the French Devenir des Spondylarthropathies Indifférenciées Récentes (DESIR; Outcome of Recent Undifferentiated Spondylarthropathies) cohort of 708 patients with recent-onset (<3 years) inflammatory back pain (IBP) suggesting axial SpA. TNFα antagonist use was recorded at months 6 and 12 and factors independently associated with TNFα antagonist therapy were identified by multivariate logistic regression.
RESULTS:
Among the 708 patients (mean age 33.8 years, 46.2% men), 166 (23.4%) patients received TNFα antagonist therapy by month 12, including 120 (73.6%) patients who fulfilled Assessment of SpondyloArthritis international Society (ASAS) axial criteria and 157 (94.6%) who fulfilled at least 1 SpA criteria set; 109 (65.6%) had no sacroiliitis. Factors independently associated with early TNFα antagonist therapy were high Ankylosing Spondylitis Disease Activity Score using the C-reactive protein level (odds ratio [OR]1-point increase 1.60, 95% confidence interval [95% CI] 1.25-2.03, P < 0.001), high physician’s global disease activity score (OR 1.37, 95% CI 1.21-1.54, P < 0.001), ASAS nonsteroidal antiinflammatory drug score >50 (OR 1.88, 95% CI 1.24-2.87, P = 0.003), current or past disease-modifying antirheumatic drug use (OR 2.09, 95% CI 1.22-3.59, P = 0.008), systemic corticosteroid use (OR 2.48, 95% CI 1.43-4.34, P = 0.002), and mild to severe radiographic hip abnormalities (OR 9.43, 95% CI 2.11-42.09, P = 0.003). After adjustment on these factors, Achilles enthesis hypervascularization by power Doppler and number of work days missed were associated with TNFα antagonist therapy.
CONCLUSION:
In the DESIR cohort, approximately one-fourth of patients with recent IBP suggestive of axial SpA were under anti-TNFα therapy after 1 year of followup. All factors associated with this early initiation reflected higher disease activity, refractoriness, or severity, which suggests compliance of French rheumatologists with current treatment guidelines.
Categories: Publication de travaux dans des journaux médicaux | Tags: cohorte DESIR, DESIR, spondyloarthristis | No Comments »
juillet 12, 2014 | Posted by admin
Un nouvel article scientifique intitulé « Effectiveness of TNF-alpha blockers in early axial spondyloarthritis. Data from the desir cohort» a été publié dans le journal Arthritis Rhheumatology
Moltó A, Paternotte S, Claudepierre P, Breban M, Dougados M.
Arthritis Rheumatol. 2014 Jul;66(7):1734-44. doi: 10.1002/art.38613.
Abstract
OBJECTIVE:
To estimate the frequency of use and effectiveness in daily practice of tumor necrosis factor α (TNFα) blockers in a population with inflammatory back pain suggestive of early axial spondyloarthritis (SpA).
METHODS:
The Devenir des Spondylarthropathies Indifférenciées Récentes (DESIR) cohort is a prospective, multicenter, observational cohort of 708 patients with early (<3 years’ duration) inflammatory back pain suggestive of axial SpA. The percentage of patients receiving TNFα blockersover the first 2 years of followup was estimated by survival analysis. To evaluate effectiveness, the primary outcome (40% improvement in disease activity according to the Assessment of SpondyloArthritis international Society criteria [ASAS40]) was compared in patients who received TNFαblockers versus control patients who received any other treatment (usual care). Controls were matched to the patients based on a propensity score method.
RESULTS:
A total of 30.2% (95% confidence interval [95% CI] 26.7-33.7) patients received at least 1 TNFα blocker during the 24 months of followup. The percentage of ASAS40 responders was 31.5% (62 of 197 patients) in the group receiving TNFα blockers versus 13.2% (26 of 197) in the control group (OR 2.99 [95% CI 1.80-4.99], P = 0.0002). This effectiveness was more pronounced in the subgroup of patients with sacroiliitis identified on magnetic resonance imaging, with 46% of ASAS40 responders receiving TNFα blockers versus 15% of ASAS40 responders receiving usual care (OR 4.99 [95% CI 2.17-11.51]).
CONCLUSION:
Our study shows that TNFα blockers are frequently used in daily practice to treat patients with early axial SpA. Our findings confirm the effectiveness of TNFα blockers as compared to any other treatment, especially in the subgroup of patients with sacroiliitis on MRI.
Categories: Publication de travaux dans des journaux médicaux | Tags: cohorte DESIR, DESIR, spondyloarthritis | No Comments »
