Smokers in early axial spondyloarthritis have earlier disease onset, more disease activity, inflammation and damage, and poorer function and health-related quality of life: results from the DESIR cohort

juin 15, 2012 | Posted by admin

Un nouvel article intitulé « Smokers in early axial spondyloarthritis have earlier disease onset, more disease activity, inflammation and damage, and poorer function and health-related quality of life: results from the DESIR cohort » a été publié le 14 novembre 2011 dans la revue Annals of Rheumatic Diseases.

Chung HY, Machado P, van der Heijde D, D’Agostino MA, Dougados M.

Ann Rheum Dis. 2012 Jun;71(6):809-16. doi: 10.1136/annrheumdis-2011-200180

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Abstract

OBJECTIVES:

To investigate the association of smoking with various clinical, functional and imaging outcomes in patients with earlyaxialspondyloarthritis (SpA).

METHODS:

647 patients with early inflammatory back pain (IBP) fulfilling at least one of the internationally accepted SpA criteria and with available smoking data were included in the analyses. Clinical, demographic and imaging parameters were compared between smokers and non-smokers at a cross-sectional level. Variables with significant differences in univariate analyses were used as dependent variables in multivariate linear and logistic regression models adjusted for potential confounding/contributing factors.

RESULTS:

Multivariate analysis showed that smoking was associated with an earlier onset of IBP (regression coefficient (B)=(-1.46), p=0.04), higherdisease activity (ankylosing spondylitis disease activity score B=0.20, p=0.03; Bath ankylosing spondylitis disease activityindex B=0.50, p=0.003), worse functional status (Bath ankylosing spondylitis functional index B=0.38, p=0.02), more frequent MRI inflammation of the sacroiliac joints (OR 1.57, p=0.02) and the spine (OR 2.33, p<0.001), more frequent MRI structural lesions of the sacroiliac joints (OR 1.54, p=0.03) and the spine (OR 2.02, p=0.01), and higher modified Stoke ankylosing spondylitis spine score (B=0.54, p=0.03) reflecting radiographic structural damage of the spine. Smoking was also associated with poorer quality of life (Euro-quality of lifequestionnaire B=1.38, p<0.001, short form 36 physical B=(-4.89), p<0.001, and mental component score B=(-5.90), p<0.001).

CONCLUSION:

In early axial SpA patients, smoking was independently associated with earlier onset of IBP, higher disease activity, increased axialinflammation on MRI, increased axial structural damage on MRI and radiographs, poorer functional status and poorer qualityof life.

Comment in : The risks of smoking in patients with spondyloarthritides. [Ann Rheum Dis. 2012]

Categories: Publication de travaux dans des journaux médicaux | Tags: annal of rheumatic diseases, axial spondyloarthritis, DESIR, disease activity | No Comments »